1st SOHO Clinical and Biological School of Acute Leukemia
نویسندگان
چکیده
Genomic and functional alterations of enzymatic activity drive cancer metabolic reprogramming along with mutations tumor suppressors oncogenes [...]
منابع مشابه
Presenting Clinical and Laboratory Data of Childhood Acute Lymphoblastic Leukemia
Abstract Background Leukemia is the most prevalent childhood cancer and Acute Lymphoblastic Leukemia (ALL) constitutes 75% of all cases. The most frequent presenting symptoms are fever, weight loss and pallor. Early detection of clinical symptoms positively affects timely diagnosis. The objectives of the present study were to assess frequency of presenting symptoms, laboratory data, immune ph...
متن کاملALL1 gene alterations in acute leukemia: biological and clinical aspects.
BACKGROUND AND OBJECTIVE The ALL1 gene, also referred to as MLL, HRX or Htrx1, is interrupted in the vast majority of translocations involving the chromosome band 11q23. Alterations in this gene are reported in approximately 5-10% of acute leukemias (AL) and characterize different leukemic subtypes such as infant (< 12 months of age) AL, topoisomerase II inhibitors-related (TR) AL and a small s...
متن کامل[Analysis of clinical-biological features of adult acute lymphoblastic leukemia].
INTRODUCCTION Acute lymphoblastic leukemia (ALL) is a clonal disease characterized by a proliferation of immature cells. In immunophenotypic, cytogenetic and molecular studies, it is a heterogeneous disease with diverse manifestations and prognoses. The treatment is complex and is associated with complications during its course. PATIENTS AND METHODS A prospective study of cohort of patients w...
متن کاملClinical and biological characteristics of adult biphenotypic acute leukemia in comparison with that of acute myeloid leukemia and acute lymphoblastic leukemia: a case series of a Chinese population.
BACKGROUND Biphenotypic acute leukemia is a rare disorder that is difficult to diagnose. It displays features of both myeloid and lymphoid lineage. There is still a lack of studies in biphenotypic acute leukemia in a Chinese population. We present here a comprehensive investigation of the clinical and biological characteristics, and outcome of biphenotypic acute leukemia in our hospital in over...
متن کاملExpression of BCL2L12 in acute leukemia patients: Potential association with clinical and prognostic factors
Introduction: Apoptosis is an important mechanism in both physiological and pathological conditions. The BCL2 family of proteins plays a critical role in regulation of apoptotic cell death. Up and down regulation of BCL2-like 12 (BCL2L12), a new member of the BCL2 family, has been reported in several malignancies. However, the expression level of BCL2L12 rarely has been studied in leukemia. T...
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ژورنال
عنوان ژورنال: Hematology Reviews
سال: 2021
ISSN: ['2038-8330', '2038-8322']
DOI: https://doi.org/10.3390/hematolrep13110001